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    2022-11-29 06:25:44÷˹ҽѧ
    ʾо3½һ֤ʵToripalimabaxitinibᣩתճĤɫЧ

    ڣJournal for ImmunoTherapy of Cancer־ϱһо3½ҪPD-1ƼToripalimabaxitinibᣩתճĤɫMMЧ

    2022-11-29-2022-11-2933ںɫ߱о(31/33)δܹȫơ31δܹƻУ2ԭ29֤ʵΪMM


    29δεIJ֤ʵΪMMУRECIST巴Ӧ1CR13PRs11ȶ(SDs)4PDirRECIST巴Ӧ1CR14PR10SD4PDRECISTirRECISTORRֱΪ48.3% (95% CI 29.4% ~ 67.5%)51.7% (95% CI 32.5% ~ 70.6%)

    2022-11-29RECISTmDoRΪ13.4(95% CI 5.520.6)RECISTλ޽չڣPFSΪ7.5(95% CI 3.8 - 14.8)RECIST123޽չʷֱΪ41.4% (95% CI 23.65% ~ 58.27%)13.8% (95% CI 4.35% ~ 28.61%)10.3% (95% CI 2.63% ~ 24.30%)λOSΪ20.7(95% CI 9.7 - 32.7)123OSʷֱΪ62.1% (95% CI 42.06% ~ 76.90%)44.8% (95% CI 26.52% ~ 61.57%)31.0% (95% CI 15.56% ~ 47.91%)

    ýʾPD- L1ԺPD- L1Իߵ޽չںOS죺λ޽չΪ13.8vs 5.9(HR 0.71 95% CI 0.32 ~ 1.55;p=0.39)λOSΪ29.6 vs 17.8(HR 0.83 95% CI 0.37 ~ 1.85;p = 0.65)

    TMBߣR6ͻ/MbpTMBͣ<6ͻ/MbpߵPFSOSû죺λPFS 14.8vs 6.7£HR 0.80 95% CI 0.331.92;p=0.61λOSֱΪ29.7º20.4£HR 0.77 95% CI 0.311.94;p = 0.59

    12֣GEPΪ450<450顣GEP<450ȽϣGEP450ߵλPFS(λPFSֱΪ17.75.7 £ HR 0.28 95% CI 0.11-0.72; p=0.0083)OS (λOSֱΪ35.617.6£HR 0.40 95% CI 0.16 to 0.95; p=0.039)ơ

    ϣо3½һ֤ʵToripalimabaxitinibᣩתճĤɫЧ

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    Li S Wu X Yan X et al. Toripalimab plus axitinib in patients with metastatic mucosal melanoma 3-year survival update and biomarker analysis. Journal for ImmunoTherapy of Cancer 2022;10e004036. doi10.1136/jitc-2021-004036.

    39רҵҽƱϢƽ̨ ʽѶŻվ    

    йȵĽŻվйǿ2022-11-29ͨйʷƾáģӵзḻӴûĽƽ̨ڽѶҽʴ𡢾ҽҩϢѯȷȣ߽Ϣ¶ȸdz4û

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